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Aug 02, 2021Abstract. The coronavirus disease 2021 (COVID-19) pandemic is among the most important public health crises of our generation. Despite the promise of prevention offered by effective vaccines, patients with severe COVID-19 will continue to populate hospitals and intensive care units for the foreseeable future.

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Histone Deacetylase 7 Regulates Cell Survival and TCR

CD4/CD8 double-positive thymocytes express the transcriptional repressor histone deacetylase (HDAC)7, a class IIa HDAC that is exported from the cell nucleus after TCR engagement.

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Protein Kinase D Signaling: Multiple Biological Functions

Feb 01, 2021Protein kinase D (PKD) is an evolutionarily conserved protein kinase family with structural, enzymological, and regulatory properties different from the PKC family members. Signaling through PKD is induced by a remarkable number of stimuli, including G-protein-coupled receptor agonists and polypeptide growth factors.

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Histone Deacetylase 7 Associates With Runx2 and Represses

Dec 04, 2021INTRODUCTION. R unx2 is an essential regulator of formation. The crucial importance of Runx2 is revealed by the phenotypes associated with alterations to its expression. Heterozygosity at the Runx2 locus results in the disorder cleidocranial dysplasia, 1 which is characterized by short stature, dental defects, and reduced or absent clavicles, whereas homozygous

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Current translational potential and underlying molecular

Nov 12, 2021Kesarwani, P. et al. Blocking TCR restimulation induced necroptosis in adoptively transferred T cells improves tumor control. Oncotarget 7, 69371–69383 (2021).

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Histone Deacetylase 7 mediates tissue

Apr 17, 2021Expressing this TCR transgene greatly increases the frequency of CD1D/αGalCer-reactive thymocytes, which arise naturally only at only around 1 in 10 4 cells. As expected, mice expressing only the Vα14 transgene had many more iNKT cells in thymus and spleen than WT mice ( Figure 3A, Figure 3—figure supplement 1A–B ).

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Member Groups

Three multi-investigator groups that operate principally in the TB/HIV space: The South African TB Vaccine Initiative (SATVI), which includes Mark Hatherill (Director), Tom Scriba (Deputy Director) and Elisa Nemes; The Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa) which includes Robert Wilkinson (Director), Graeme Meintjes, Catherine Riou and Anna Coussens

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A portrait of the immune response to proliferative kidney

May 13, 2021A decrease in myeloid cells and the in situ proliferation of lymphocytes are the most notable cellular aspects of PKD pathogenesis. 33, 34 Comprehensive transcriptional studies have revealed the regulation of a number of important genes related to T‐helper (Th)‐like functions, a dysregulated B‐cell antibody type response and also the

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Addgene's ready-to-use AAV preparations include tools for serotype testing, optogenetics, chemogenetics, biosensors, retrograde AAV, and more. Addgene's COVID-19 collection includes plasmids expressing SARS-CoV-2 open reading frames, ACE2, TMPRSS2, FURIN, and more. Addgene's repository contains over 100,000 plasmids.

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Zebrafish as an alternative animal model in human and

May 07, 2021Much of medical research relies on animal models to deepen knowledge of the causes of animal and human diseases, as well as to enable the development of innovative therapies. Despite rodents being the most widely used research model worldwide, in recent decades, the use of the zebrafish (Danio rerio) model has exponentially been adopted among the scientific community.

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Phosphorylation of histone deacetylase 7 by protein kinase

Feb 28, 2021PKD is activated by TCR signaling in thymocytes. If PKD is involved in the nuclear exclusion of HDAC7, then TCR signaling would be expected to activate PKD in DO11.10 cells. Autophosphorylation of serine 916 follows activation of PKD and can thus be used as a marker for PKD activity . We used an antibody specific for phosphorylated serine 916

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